af869 jnk rabbit Search Results


p jnk  (R&D Systems)
94
R&D Systems p jnk
P Jnk, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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af869 jnk rabbit  (Proteintech)
96
Proteintech af869 jnk rabbit
Af869 Jnk Rabbit, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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erk1/2 (m5670)  (Millipore)
90
Millipore erk1/2 (m5670)
Erk1/2 (M5670), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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smad2  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc smad2
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
Smad2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/smad2/product/Cell Signaling Technology Inc
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p jnk 9251  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc p jnk 9251
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
P Jnk 9251, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p-erk1/2 (m8159)  (Millipore)
90
Millipore p-erk1/2 (m8159)
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
P Erk1/2 (M8159), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p-p38  (R&D Systems)
90
R&D Systems p-p38
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
P P38, supplied by R&D Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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jnk  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc jnk
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
Jnk, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phospho smad2  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc phospho smad2
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
Phospho Smad2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gapdh (glyceraldehyde-3-phosphate dehydrogenase) (mab374)  (Millipore)
90
Millipore gapdh (glyceraldehyde-3-phosphate dehydrogenase) (mab374)
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
Gapdh (Glyceraldehyde 3 Phosphate Dehydrogenase) (Mab374), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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monoclonal phospho-p38 (thr180/thy182) antibody  (R&D Systems)
90
R&D Systems monoclonal phospho-p38 (thr180/thy182) antibody
Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. <t>Phospho-smad2</t> nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).
Monoclonal Phospho P38 (Thr180/Thy182) Antibody, supplied by R&D Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. Phospho-smad2 nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).

Journal: Clinical Cancer Research

Article Title: LY2109761 Attenuates Radiation-Induced Pulmonary Murine Fibrosis via Reversal of TGF-β and BMP-Associated Proinflammatory and Proangiogenic Signals

doi: 10.1158/1078-0432.ccr-11-2855

Figure Lengend Snippet: Figure 4. Lung histology. Representative examples of histology of mouse lungs treated with 20 Gy LY2109761 at day 2, weeks 6, 16, 20 after the irradiation. Radiation-induced increasing wall thickening and collagen deposition along with alterations in the epithelium of bronchi and bronchioles, and in some cases edema; all were attenuated by LY2109761. Untreated control (no RT) and LY only is similar and LY, RT, LY is similar to LY, RT and RT, LY. A, Goldner–Elastica. B, H&E. C, Sirius Red. D, representative examples of immunohistochemistry of lung tissue at week 20 after radiation. Phospho-smad2 nuclear immunopositivity is displayed. E, the amount of nuclear immunopositivity in the alveolar septae and the intensity of the nuclear immunopositivity of alveolar macrophages were scored on a rank scale base (0, 1, 2, 3, 4). Bars are median (, P < 0.05 vs. radiation, RT).

Article Snippet: Antibodies for Western blotting were: SMAD2 (Cell signaling; 3122) and phospho-SMAD2 (Cell signaling; 3108), SMAD1 (Cell signaling; 9743) and p-SMAD1 463/465 (Cell signaling; 9516), p38 (R&D), p-p38 (R&D; AF869), c-jun-NH2-kinase (JNK, R&D; mab2076), p-JNK (R&D; af1205), and smoothmuscle actin (SMA; Abcam ab5694-100).

Techniques: Irradiation, Control, Immunohistochemistry